For those of you who don't know him, here is an introduction from wikipedia:
Randolph Frederick Pausch (October 23, 1960 – July 25, 2008) was an American professor of computer science, human-computer interaction and design at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania, and a best-selling author who achieved worldwide fame for his "The Last Lecture" speech on September 18, 2007 at Carnegie Mellon.
In August 2006, Pausch was diagnosed with pancreatic cancer. He pursued a very aggressive cancer treatment that included Whipple procedure surgery and experimental chemotherapy; however, in August 2007 he was told the cancer had metastasized to his liver and spleen, which meant it was terminal. He then started palliative chemotherapy, intended to extend his life as long as possible. At that time, doctors estimated he would remain healthy for another three to six months. On May 2, 2008, a PET scan showed that his cancer had spread to his lungs and some lymph nodes in his chest, and that he had some metastases in his peritoneum and retroperitoneum.
Pausch delivered his "Last Lecture," titled "Really Achieving Your Childhood Dreams," at CMU on September 18, 2007. This talk was modeled after an ongoing series of lectures where top academics are asked to think deeply about what matters to them, and then give a hypothetical "final talk," i.e., "what wisdom would you try to impart to the world if you knew it was your last chance?"
Before speaking, Pausch received a long standing ovation from a large crowd of over 400 colleagues and students. When he motioned them to sit down, saying, "Make me earn it," some in the audience shouted back, "You did!"
During the lecture, Pausch was upbeat and humorous, alternating between wisecracks, insights on computer science and engineering education, advice on building multi-disciplinary collaborations, working in groups and interacting with other people, offering inspirational life lessons, and performing push-ups on stage.